US-2367-95

Abstract

Achievements

Lymphocyte Response to Genetically Engineered Bovine Leukemia Virus Proteins in Persistently Lymphocytic Cattle from Israel and the U.S.	Budget	Duration
	$300,000	3 years

	Brenner, Y.	Isr. Vet. Inst.
	Trainin, Z.	Isr. Vet. Inst.
	Splitter, G.A.	U Wisconsin

Publication List

Trainin, Z., J. Brenner, H. Ungar-Waron and B. Yakobson (1998). Cytokine regulation in experimental models of bovine leukemia virus infection. Keystone Symp., Molecular aspects of viral immunity. Tamarron, Colorado, USA :

Ungar-Waron, H., R. Paz, J. Brenner, B. Yakobson and Z. Trainin (1998). Circulating B and yST lymphocytes in calves following experimental infection with bovine leukemia virus (BLV). 4th Intl. Cong. of Veterinary Virology, Edinburgh, Scotland. :

Ungar-Waron, H., R. Paz, J. Brenner, B. Yakobson, N. Partosh and Z. Trainin (1998). A model of bovine leukemia virus (BLV) retroviral infection in young calves. 5th IUBMB Conference on the Biochemistry of Health and Disease. Jerusalem, Israel. :

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1997). Early shift from type 1 to type 2 cytokine expression during experimental BLV infection may direct disease progression. 4th Intl. Cong. of Veterinary Virology, Edinburgh, Scotland :

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1998). Cellular immune response cytokine expression directs the disease rogression in bovine leukemia virus infection. 5th IUBMB conference on the Biochemistry of Health and Diseases. Jerusalem, Israel. :

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1998). The role of IFN-y in the immunopathology of bovine leukemia virus infection. Second Joint Meeting International Society of Interferon and Cytokine Reasearch, Jerusalem, Israel. :

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1996). Detection of bovine leukemia proviral DNA or viral RNA in serum of infected cattle by polymerase chain reaction. Xth International Congress of Virology, Jerusalem :

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1996). Interleukin-12 gene expression after experimental bovine leukemia virus infection in calves. Intl. Symp. Cytokines and Type I, Type II Paradigm. Cairns, Australia :

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1997). Initial and delayed cytokine immune response in cattle after BLV infection. The 1st Intl. Workshop on Virus Diseases of Humans, Animals, Fish and Plants. Eilat, Israel. :

Yakovson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1997). Increased and extended expression of IFN-y delays progression of persistent lymphocytosis at early stages of experimental BLV infection. The XXVth Anniversary meeting of the International Society for Oncodevelopmental Biology and Medicine. Montreux, Switzerland. :

Orlik, O. and G.A. Splitter (1996). Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlates with impaired proliferation 0f CD4+ T-cells in response to gag- and env-encoded BLV proteins.   J Virol 70:7584-7593

Orlik, O. and G.A. Splitter (1996). Optimization of lymohocyte proliferation assay for cells with high spontaneous proliferation in vitro: CD4+ T-cell proliferation in bovine leukemia virus infected animals with persistent lymphocytosis.   J Immunol Methods 199:159-165

Orlik, O., C. Altane and G.A. Splitter (1997). Temperature-dependent nonspecific adsoption of recombinant bovine leukemia virus receptor BLVRcpl in immunoassay.    J Immunoass 18:185-198

Orlik, O., J. Ban, J. Hlavaty, C. Altner, R. Kettmann, D. Portetelle and G.A. Splitter (1997). Polyclonal bovine sera but not virus-neutralizing monoclonal antibodies block bovine leukemia virus (BLV) gp51 binding to recombinant BLV receptor BLVR cp1.   J Virol 71:3263-3267

Pyeon, D. and G.A. Splitter (1998). Interleukin-12 mRNA expression in alymphocytotic animals infected with bovine leukemia virus.   J Virol 72(8):6917-6921

Pyeon, D., K.L. O'Reilly and G.A. Splitter (1996). Increased interleukin-10 mRNA expression in tumor bearing or persistently lymphocytotic animals infected with bovine leukemia virus.   J Virol 70:5706-5710

Ungar-Waron, H., R. Paz, J. Brenner and Z. Trainin (1999). Detection of IL-12 on peripheral blood mononuclear cells of bovine leukemia virus-infected calves by FACS analysis.     Isr J Vet Med 54:57-60

Ungar-Waron, H., R. Paz, J. Brenner, B. Yakobson, N. Partosh and Z. Trainin (1999). Experimental infection of calves with bovine leukemia virus (BLV): an applicable model fo a retroviral infection.   Vet Immunol Immunopathol 67:195-201

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (2000). Cellular immune response cytokine expression during the initial stage of BLV infection determines the disease progression to persistent lymphocytosis.   Commun Soil Sci Plant Anal 23:197-208

Yakobson, B., J. Brenner, H. Ungar-Waron and Z. Trainin (1998). Short-termed expression of IL-12 during experimental BLV infection may direct disease progression to persistent lymphocytosis.   Vet Immunol Immunopathol 64:207-218